Triprolidine – Pseudoephedrine

What is Triprolidine – Pseudoephedrine and how does it work?

Triprolidine – Pseudoephedrine is a combined medicine. This is used to relieve symptoms such as the runny nose and sinus congestions associated with flu, cold, and nasal allergies. Triprolidine is a sedating antihistamine and Pseudoephedrine a decongestant. Triprolidine – Pseudoephedrine is a prescription approved by the Food and Drug Administration (FDA). This comes as a tablet for oral use. 

Pseudoephedrine works by acting on alpha receptors that can be found in the walls of blood vessels. It is particularly in the linings of nasal passages and sinuses. It causes these blood vessels to contract and narrow. In that way, it decreases the blood flow into the linings of the sinuses and nose. Pseudoephedrine relieves a blocked nose and sinus congestion associated with conditions such as flu, colds, and nasal allergies. 

Triprolidine prevents the actions of histamine. By blocking the histamine receptors, it prevents the actions of histamine which lessens the production of mucus in the nose. Histamine is a substance produced naturally by the body that has many effects. The substance that is produced naturally may include the production of allergic symptoms such as the runny nose. 

Runny nose

This is a symptom of numerous conditions and is characterized by mucus dripping from the nostril. Sometimes, inflammation and irritation in the nasal passage can lead to increased mucus production. When this occurs, excess mucus can drip from the nose. A runny nose can be caused by a foreign body, polyps, a tumor, or a migraine-like headache. Some causes of the runny nose may also include:

  • Allergies
  • Acute sinusitis 
  • Common cold
  • Chronic sinusitis 
  • Decongestant nasal spray overuse
  • Dry air
  • Hormonal changes
  • Influenza or flu
  • Pregnancy
  • Tobacco smoke 

Sinus congestions

This condition is most commonly the result of inflammation and swelling of the lining tissues of the nasal passages and sinuses. Common symptoms of sinus congestion may include:

  • Pressure in your face and eyes
  • Head stuffiness
  • Difficulty breathing through the nose
  • Pressure-like pain behind the eyes, in the face, or toothache
  • Runny nose
  • Postnasal drip and sore throat 

If you have the following symptoms, call your doctor right away:

  • Nasal discharge that has a bad smell
  • Swelling of the forehead, face, or eyes
  • Symptoms lasting more than 3 weeks 
  • Nasal discharge from only one side
  • Fever 

Normally, your sinuses are empty, air-filled spaces that moisten, warm, and filter air breathed through the nose. The cavities’ lining produces mucus that is moved out of the sinuses and nasal passages by small hairs. Inflammation due to infection or an allergic reaction can result in excessive mucus. It will also be difficult for it to drain from the sinuses. Sinus congestion is often seen with other symptoms that may point toward the cause. If it seems to be part of an uncomplicated cold or the flu, you might not need to seek a further diagnosis. Frequently, these will go away their own after a few days. 

How to use Triprolidine – Pseudoephedrine?

This medication is taken by mouth as directed by your doctor. Each dose may be taken with food if stomach upset occurs. Drink plenty of fluids unless otherwise directed by your doctor. Do not crush or chew the tablets. Doing so can release the entire drug at once and increases the risk of side effects. Swallow the tablet as a whole without crushing or chewing. 

Dosage is based on your medical condition, age, and response to the treatment. You should not increase your dose or take this medication more often than directed without the approval of your doctor. Improper use of this drug may result in serious harm. If your doctor directs you to take this medication daily, take it regularly to get the most benefit from it. To help you remember, take it at the same time and in the same way each day. 

Let your doctor know if your condition persists for more than a week, if it worsens, or if it occurs with rash, fever, or persistent headache. These may be symptoms of a serious medical problem and should be checked by a doctor. 

What are the side effects of Triprolidine – Pseudoephedrine?

Common side effects:

  • Dry mouth, throat, or nose
  • Drowsiness
  • Headache
  • Feeling sick or vomiting 
  • Restlessness
  • Anxiety 
  • Difficulty sleeping or insomnia 
  • Increased heart rate 
  • Rash
  • Awareness of your heartbeat or palpitations 
  • Hallucinations 
  • Difficulty passing urine 

Medicines and their possible side effects can affect individual people in different ways. If these side effects persist or get worse, call for medical help right away. 


  • You should not use this medicine with another cough, cold and flu or decongestant medicines unless they have been specifically recommended by your pharmacist. This is because these combination cold and flu products may contain the same active ingredients and using more than one at the same time. It could lead to you exceeding the recommended dose or having a greater chance of getting side effects.
  • Pseudoephedrine can oppose the effects of medicines to treat high blood pressure. If you are taking medicines for high blood pressure you should not take this medication.
  • You may get dizzy or drowsy. Do not use machinery, drive, or do anything that needs mental alertness. You may do it until you know how this medicine affects you. Do not stand or sit up quickly especially if you are an older patient. This reduces the risk of dizzy or fainting spells. 
  • Avoid alcoholic drinks. Alcohol may interfere with the effect of this medicine.
  • Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
  • This medicine may cause blurred vision and dry eyes. You may feel some discomfort if you wear contact lenses. Some lubricating drops may help. See your eye doctor if the problem does not go away or is severe.
  • Store at room temperature between 15 and 30 degrees C. Protect from light. Keep the container tightly closed. Throw away any unused medicine after the expiration date.