Tacrine Hydrochloride

Where is Tacrine Hydrochloride used?

Tacrine Hydrochloride is used for the treatment of mild to moderate dementia in patients with Alzheimer’s disease such as:

  • Abstract thinking
  • Impairment of memory or judgment
  • Changes in personality

This medication will not cure the disease and will not stop the disease from getting worse. Still, this treatment can improve thinking ability in some patients with this condition.

Tacrine Hydrochloride is in a class of medications known as cholinesterase inhibitors. The Food and Drug Administration (FDA) approved this in the year 1993.

How does Tacrine Hydrochloride work?

Tacrine Hydrochloride inhibitors block the action of acetylcholinesterase. It is the enzyme accountable for the damage of acetylcholine.

Acetylcholine is one of the neurotransmitters in the brain. It is the chemicals that nerve cells use to connect. Reduced levels of acetylcholine in the brain are believed to be responsible for some of the symptoms of Alzheimer’s disease. By blocking the enzyme that destroys acetylcholine, this drug increases the concentration of acetylcholine in the brain. This increase is believed to be responsible for the improvement in thinking.

How is Tacrine Hydrochloride taken?

Use Tacrine Hydrochloride exactly as the prescription of your doctor. The recommended dosage is based on your condition and response. The usual starting dose of this is 10 mg to 20 mg to be taken four times a day. The maximum dose is 160 mg daily. This is usually taken on an empty stomach an hour before or two hours after a meal. If a stomach upset occurs, you may take it with food to lessen stomach irritation. Take it on a regular schedule and at the same time each day.

It is important to use this medication regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. Your doctor may sometimes change your dosage to make sure you get the best results from this medicine.

Do not change your dose without approval from your doctor. Taking this medication inappropriately may lead to serious behavioral side effects or a worsening of Alzheimer’s symptoms.

What are the possible side effects of Tacrine Hydrochloride?

  • Mild nausea
  • Diarrhea
  • Vomiting
  • Urinating more than usual
  • Upset stomach
  • Increased sweating
  • Skin rash
  • Cough
  • Runny nose
  • Fever or chills
  • Dizziness
  • Drowsiness
  • Tired feeling
  • Lack of coordination or weakness
  • Joint or muscle pain

Call your doctor right away if these happen:

  • Hallucinations
  • Extreme or sudden changes in behavior
  • Confusion
  • Pain or burning when you urinate
  • Jaundice
  • Stomach pain
  • Loss of appetite

What are the precautions in taking Tacrine Hydrochloride?

  • Do not use this medication if you are allergic to it.
  • Let your doctor know if you have any medical history or current medications.
  • Consult your doctor if you are a pregnant or breastfeeding woman before taking a dose of this medication. Call your doctor right away if you get pregnant while taking this drug.
  • This may not be recommended for use in children. Consult your doctor first.
  • It is important to let your doctor know if you have kidney or liver disease.