Procyclidine Hydrochloride

Procyclidine Hydrochloride is a prescription used to treat and relieve the symptoms of Parkinson’s disease such as:

  • Problems writing, talking, and walking
  • Stiff muscles, paralysis, and tremor
  • Sweating and uncontrolled eye movements
  • Producing too much saliva and dribbling
  • Depression

Parkinson’s disease is a movement disorder that affects the nervous system. In this disease, the symptoms become worse over time. They often start with a slight tremor in one hand and a feeling of stiffness in the body. Most of the symptoms result from a fall in dopamine levels. Dopamine is produced in a part of the brain called the substantia nigra. In Parkinson’s disease, the cells of the substantia nigra start to die. This disease does not directly cause people to die but it can place great strain on the body. It can as well make some people more vulnerable to serious and life-threatening infections.

This medication may also be used to stop side effects called extrapyramidal effects which are caused by some medicines. These may include signs similar to Parkinson’s disease or restlessness and unusual head and body movements. These effects are also called drug-induced movement disorders. Extrapyramidal function refers to our motor control and coordination. It also includes being able to not make movements we don’t want to make.

Procyclidine Hydrochloride is a type of medicine called anticholinergic and sometimes called antimuscarinics. This blocks a certain natural substance. This helps decrease sweating, muscle stiffness, and improves walking ability. The Food and Drug Administration (FDA) has already approved this medicine. Each scored tablet has 5 mg of Procyclidine Hydrochloride as an active ingredient. This product is for oral use.

How does Procyclidine Hydrochloride work?

Anticholinergic medicines like Procyclidine Hydrochloride prevents the activity of a neurotransmitter called acetylcholine. Neurotransmitters are chemical compounds that are found in the brain and nerves. They act as a chemical messenger between the nerve cells. There are many different neurotransmitters in the body and these have various different functions.

In Parkinson’s disease, there is a deficiency of a neurotransmitter called dopamine in the brain. Wherein, it causes the overactivity of acetylcholine. Procyclidine Hydrochloride blocks the receptors that acetylcholine acts on. This decreases the activity of acetylcholine and helps restore the balance of acetylcholine and dopamine in the brain. In this way, this medication helps control some of the symptoms of the disease. It is most effective at decreasing the tremor and rigidity associated with the disease.

How to use Procyclidine Hydrochloride?

The recommended dosage is based on your medical condition, age, and response to the treatment. Your doctor may direct you to start at a lower dose and eventually increase it. You should take the right dose, not more or less. Do not suddenly stop taking this medication without the consent of your doctor. It may cause another complication or may worsen your current condition. For the best benefit from this product, take it regularly. If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for the missed dose. Let your doctor know if your condition does not improve or if it gets worse.

Procyclidine Hydrochloride is usually taken 3 to 4 times a day after meals and at bedtime or as directed by your doctor. You must take each tablet by mouth. Swallow the tablet as a whole with a full glass of water. Do not break, chew, or crush it. Drink plenty of fluids while having this medication. Doing so may lessen the risk of certain side effects. Remember to take it at the same time and in the same way each day. If you are taking antacids, take this medication at least an hour before you take antacids. Allow at least 1to 2 hours between doses of Procyclidine Hydrochloride and certain drugs for diarrhea. Antacids and some drugs for diarrhea may prevent the full absorption of this product. It may also prevent full absorption if the medicines are taken together. When used for an extended period, this medication may not work as well and may require different dosing.

What are the side effects of Procyclidine Hydrochloride?

Common side effects:

  • Dizziness
  • Drowsiness
  • Constipation
  • Light-headedness
  • Nausea
  • Flushing
  • Abdominal pain
  • Vomiting
  • Blurred vision
  • Nervousness
  • Dry mouth
  • Weakness

Tell your doctor right away if you have serious side effects such as:

  • Severe stomach or abdominal pain
  • Painful or difficulty swallowing
  • Difficulty urinating
  • Decreased sexual ability

Call for emergency medical help if you have signs of an allergic reaction like:

  • Severe dizziness
  • Trouble breathing
  • Rash or itching
  • Swelling tongue, face, and throat

Warnings and Precautions

  • Let your doctor know if you have any medical history such as heart problems, high/low blood pressure, certain nerve disease, and kidney disease.
  • This medication lessens the production of saliva. It is an effect that can increase gum and tooth problems. Take special care with your dental hygiene and have a regular dental check-up.
  • This causes decreased sweating which can cause a severe rise in your body temperature. Drink plenty of fluids and dress lightly while in hot weather and when exercising.
  • Children may be more sensitive to the effects of this drug especially effects on heart rate.
  • This prescription should not be given in children.
  • You may have confusion, blurred vision, or dizziness while taking Procyclidine Hydrochloride. If this happens do not drive or use any machinery that requires your alertness. Do it until you know how this drug affects you and your performance.
  • Do not use this for the treatment of other illnesses without the consent of your doctor.
  • This should only be used when needed in pregnant women. If you are breastfeeding women, consult your doctor first before using this medicine.

Procyclidine Hydrochloride should be used with caution in:

  • Elderly people
  • Those with decreased liver or kidney function
  • People at risk or glaucoma and obstruction of the stomach or intestines

This should not be used in people with:

  • Obstruction of the stomach or intestines
  • Closed-angle glaucoma
  • Untreated difficulty in passing urine