Pramipexole Dihydrochloride

Pramipexole Dihydrochloride is a prescription used for the treatment of Parkinson’s disease. It is a progressive neurological disorder and has the first sign of problems with movements. In Parkinson’s disease, the cells of substantia nigra start to die. Smooth and coordinated muscle movements of the body are made possible by a substance in the brain called dopamine. Dopamine is produced in a part of the brain called the ‘substantia nigra’. Parkinson’s is a type of disease that is chronic and worsens over time. Symptoms begin gradually, often on one side of the body and later they will affect both sides. They include:

  • Stiffness of the arms, trunk, and legs
  • Trembling of hands, legs, arms, jaw, and face
  • Poor balance and coordination
  • Slowness of movement

As symptoms worsen, people with this type of disease may have trouble walking, talking, or do simple tasks. They may also have problems such as trouble chewing, depression, sleep problems, or trouble speaking. Parkinson’s disease usually begins around the age of 60 but it can start earlier. It is more common in men than in women.

This medication may also be used for the treatment of restless legs syndrome (RLS). RLS causes an uncontrollable urge to move your legs. Usually, it is because of an uncomfortable sensation. It typically occurs in the evening or nighttime hours when you are sitting or lying down. Moving eases the unpleasant feeling temporarily. The chief symptom is an urge to move the legs.

Pramipexole Dihydrochloride helps improve your ability to move and lessen shakiness or tremors in Parkinson’s disease. It also improves slowed movement and unsteadiness. In RLS, this medication can decrease the symptoms and thereby improve sleep. Pramipexole Dihydrochloride is a dopamine agonist that helps restore the balance of a certain natural substance in the brain. The Food and Drug Administration (FDA) has already approved this prescription. This is supplied as tablets for oral use. Each tablet is available in the dosage forms of 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, and 1.5 mg.

How does Pramipexole Dihydrochloride work?

Pramipexole Dihydrochloride works by imitating the activity of a substance in the brain called dopamine. Dopamine is a substance known as a neurotransmitter. Neurotransmitters are present in the nervous system and in the brain. These are also involved in transmitting messages between nerves. These messages allow the normal functioning of the body. The neurotransmitter dopamine is known to be reduced in the brains of people with Parkinson’s disease. This is thought to be the cause of disease symptoms. Dopamine usually transmits messages by stimulating specific receptor sites in the brain. This medication stimulates these same receptor sites. This creates the same effects as dopamine and acts as a dopamine substitute. In this way, Pramipexole helps to restore the dopamine activity in the brain which helps lessen the symptoms of Parkinson’s disease.

How to use Pramipexole Dihydrochloride?

Pramipexole Dihydrochloride is to be taken by mouth as directed by your doctor. You may take each tablet with or without a meal. The prescribed dosage is based on your medical condition and response to the treatment. Your doctor may direct you to start at a lower dose and eventually increase it. Do not suddenly stop taking Pramipexole Dihydrochloride without the consent of your doctor. It is important to continue taking this even if you feel well. It is important that you take this medication exactly as it is given by your doctor. You should not take less or more often than the prescription.

To help you remember, take it at the same time and in the same way each day. Swallow the tablet as a whole with a full glass of water. Do not break, chew, or crush it. Drink plenty of fluids while having this treatment. Doing so may lessen the risk of certain side effects. If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for the missed dose. Let your doctor know if your condition worsens or does not improve.


What are the side effects of Pramipexole Dihydrochloride?

Common side effects:

  • Nausea
  • Dizziness when standing
  • Stomach pain
  • Dry mouth
  • Constipation
  • Vomiting
  • Spinning sensation
  • Headache
  • Swelling in your hands and feet
  • Drowsiness
  • Blurred vision
  • Appetite or weight changes
  • Memory problems
  • Sleep problems (unusual dreams or insomnia)
  • Confusion or thinking problems
  •  Forgetfulness
  • Impotence or trouble having an orgasm

Call your doctor right away if these occur:

  • Hallucinations
  • A light-headed feeling like you might pass out
  • Falling asleep suddenly
  • Extreme drowsiness
  • Vision problems
  • Unexplained muscle pain, weakness, or tenderness
  • Posture changes you cannot control

Warnings and Precautions

  • Before using Pramipexole Dihydrochloride, let your doctor know if you had any medical history especially of heart problems, low blood pressure, and kidney problems.
  • It is recommended that people with heart disease should have their blood pressure monitored during treatment with this medicine. Particularly, it is at the start due to the risk of drops in blood pressure.
  • You should exercise caution when driving or performing any activities. This drug may cause dizziness or sleepiness.
  • Caution should also be observed when drinking alcohol or taking other medicines that cause drowsiness, as this may increase the risk of drowsiness.
  • Consult your doctor if you have any disturbances in your vision while taking Pramipexole Dihydrochloride.
  • Use this medication with caution in people with decreased kidney function, psychotic illness, and severe disease involving the heart and blood vessels.
  • This should not be used in pregnant or breastfeeding women.
  • The safety and efficacy of this drug have not been established in children and adolescents less than 18 years of age.
  • If you have an allergic reaction to this drug before, do not use it anymore and inform your doctor. This may contain an inactive ingredient that causes an allergic reaction.
  • Do not share this or any of your medications with others even if they have the same symptoms as yours.