Minocycline Hydrochloride

Minocycline Hydrochloride is known as a broad-spectrum antibiotic. This is used to treat a wide range of infections caused by bacteria, skin infections, pelvic inflammatory disease, and preventative treatment for meningitis carriers. 

Wide range of infections caused by bacteria

Urinary tract infections don’t always cause signs and symptoms, but when they do they may include:

  • A burning sensation when urinating
  • A strong urge to urinate
  • Passing frequent, small amounts of urine
  • Urine that appears bright pink or cola-colored is a sign of blood in the urine
  • Urine that appears cloudy
  • Strong-smelling urine
  • Pelvic pain in women especially in the center of the pelvis and around the area of the pubic bone

Urinary tract infections usually happen when bacteria enter the urinary tract through the urethra and begin to multiply in the bladder. Although the urinary system is designed to keep out such microscopic invaders, these defenses sometimes fail. When that happens, bacteria may take hold and grow into a full-blown infection in the urinary tract.

Gonorrhea is caused by a sexually transmitted bacterium that infects both males and females. This condition most often affects the throat, urethra, or rectum. In females, gonorrhea can also infect the cervix. In many cases, gonorrhea infection causes no symptoms. Symptoms, however, can affect many sites in your body, but commonly appear in the genital tract. Sexually active women younger than 25 and men who have sex with men are at increased risk of getting gonorrhea. Other factors that can increase your risk include:

  • Having a sex partner who has other partners
  • Having a new sex partner
  • Having had gonorrhea or another sexually transmitted infection
  • Having more than one sex partner

Skin infections

Your skin is your body’s largest organ. One of its functions is to cover and protect your body. It helps keep germs out. But sometimes the germs can cause a skin infection. This often happens when there is a break or wound on your skin. It can also happen when your immune system is weakened, because of another disease or medical treatment. Some skin infections cover a small area on the top of your skin. Other infections can go deep into your skin or spread to a larger area. 

Pelvic inflammatory disease

This frequently happens when sexually transmitted bacteria spread from your vagina to your uterus, fallopian tubes, or ovaries. Less commonly, bacteria can enter your reproductive tract anytime the normal barrier created by the cervix is disturbed. This can happen during menstruation and after childbirth, abortion, or miscarriage. Rarely, bacteria can also enter the reproductive tract during the insertion of an intrauterine device. It is a form of long-term birth control or any medical procedure that involves inserting instruments into the uterus.


This is an inflammation of the membranes that surround the brain and spinal cord. The swelling from meningitis typically triggers symptoms such as headache, fever, and a stiff neck. Early meningitis symptoms may mimic the flu (influenza). Symptoms may develop over several hours or a few days.

How it Works

Minocycline Hydrochloride works by stopping the growth of bacteria. To make sure the bacteria causing an infection are susceptible to minocycline your doctor may take a tissue sample. 

This medicine may also work for the treatment of acne. The bacteria associated with acne are called Propionibacterium acnes. This is a common type of bacteria that feeds on sebum produced by the sebaceous glands in the skin. It produces waste products and fatty acids that irritate the sebaceous glands that make them inflamed and causing spots. By controlling bacterial numbers, Minocycline brings the inflammation of the sebaceous glands under control and allows the skin to heal.

How to Use

Minocycline Hydrochloride is usually taken twice a day every 23 hours. The dosage will depend on your condition and response. This can be taken either with or without food. Swallow the medicine as a whole with plenty of water and don’t lie down just after taking a dose to avoid irritating the throat. If you forget to take a dose, take it as soon as you remember unless it’s nearly time for your next dose. In this case, just leave out the missed dose and take your next dose as usual. Do not take a double dose to make up for a missed dose. Finish the prescribed course of this medicine even if you feel better or it seems the infection has cleared up. Stopping the course early increases the chance that the infection will return and that the bacteria will grow resistant to the antibiotic, 

Possible Side Effects

  • Fatigue
  • Nausea
  • Hives
  • Drowsiness
  • Mood changes
  • Dizziness
  • Itching
  • Joint pain
  • Ringing in the ears
  • Muscle pain
  • Dry mouth 
  • Spinning sensation or vertigo
  • Malaise 

Who should not take Minocycline Hydrochloride?

  • Children under 12 years of age
  • Women who are pregnant. This drug can be deposited in the baby’s growing bone that will affect the development of the skeleton and in teeth.
  • Women who are breastfeeding. This drug may pass into breast milk, which may cause staining of a nursing infant’s teeth 
  • People with kidney failure
  • People who are allergic to any ingredient of the medicine. Check the ingredients of your medicine if you know you have specific allergies.
  • People who are allergic to other tetracycline-type antibiotics. Make sure your doctor knows if you’ve ever had an allergic reaction to an antibiotic.

Other medicines you can take with Minocycline Hydrochloride

Before you take Minocycline Hydrochloride, tell your doctor if you’re already taking any medicines including those bought without a prescription and herbal medicines. Also, always check with your doctor before taking any new medicines while you’re taking this medication. 

If you need to take a painkiller while you’re taking this drug it’s fine to take ibuprofen or paracetamol.

Minocycline doesn’t affect hormonal contraceptives. However, if you experience vomiting or diarrhea while taking this antibiotic, this can potentially make your pill less effective at preventing pregnancy. If this happens to you, follow the instructions for vomiting and diarrhea. 

  • Anticoagulants

Minocycline may increase the anti-blood-clotting effects of coumarin anticoagulant medicines. If you’re taking warfarin your doctor may want to check your blood clotting time after you start and finish treatment with Minocycline Hydrochloride.