Where is Idelalisib used and how it works?

Idelalisib is a kinase inhibitor used for the treatment of;

  • Chronic lymphocytic leukemia (CLL)
  • Follicular lymphoma

This medicine works by blocking a protein called PI3K inside cancer cells which tell cancer to grow. Some lymphomas and leukemia cells have too much PI3K. So, by blocking this protein, Idelalisib may shrink cancer or stop it from growing for some time. 

How is Idelalisib taken?

Idelalisib is taken twice a day by mouth. Each dose may be taken either with or without a meal. If you miss a dose and it is less than 6 hours since your dose was due, take the dose right away. If you miss a dose and it is more than 6 hours since the last dose, then skip that dose and take your regular dose at the next scheduled time. Do not take 2 doses at once to make up for a missed dose.

It is important to make sure you are taking the correct amount of medication every time. The dosage is based on your medical condition and response to the treatment. Drink plenty of fluids while having this treatment. Doing so may lessen the risk of certain side effects. Do not suddenly stop taking Idelalisib without the consent of your doctor. It is important to continue taking this even if you feel well. To help you remember, take it at the same time and in the same way each day. Inform your doctor at once if your condition gets worse. 

What are the side effects of Idelalisib?

  • Nausea
  • Vomiting 
  • Abdominal pain 
  • Cough
  • Chills
  • Infection 
  • Rash
  • Chills
  • Tiredness
  • Diarrhea
  • Low blood sodium
  • High blood sugar 

What are the precautions in taking Idelalisib?

  • You have blood tests before and during your treatment. The levels of your blood cells and other substances in the blood will be checked. 
  • The blood levels of this medication can be affected by certain foods and medications, they should be avoided. These include grapefruit juice, grapefruit, Rifampin, dexamethasone, or paroxetine. Make sure to tell your doctor or healthcare provider about all medications and supplements you take. 
  • You may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future. Men might be able to store sperm before starting treatment. Women might be able to store eggs or ovarian tissue as well. but, these services are not available in every hospital, so you would need to ask your doctor about it. 
  • This treatment might harm a baby developing in the womb. It is important not to become pregnant or father a child while you’re having treatment and for a few months afterward. You may talk to your doctor about effective contraception before starting the treatment. 
  • Do not breastfeed while having this treatment because the drug may come through into your breastmilk. 
  • You should not have immunizations with live vaccines while you’re having treatment and for up to 12 months afterward. The length of time depends on the treatment you are having. 
  • Ask your doctor before scheduling dental appointments. 
  • If any unusual signs occur while you are taking this drug, call your doctor right away.