Goserelin Acetate Implant

What is Goserelin Acetate Implant and how does it work?

Goserelin Acetate is in the class of medication called gonadotropin-releasing hormone (GnRH) agonists. This is used;

  • In combination with radiation therapy and other medications to treat localized prostate cancer 
  • Alone to treat symptoms associated with advanced prostate cancer
  • To treat advanced breast cancer in certain women 
  • To manage endometriosis
  • To help with the treatment of abnormal bleeding of the uterus 

Most prostate cancers need supplies of the male hormone testosterone to grow. Testosterone is an androgen produced by the testes and adrenal glands. The production of testosterone can be stopped by surgically removing the testicles or through medication therapy. A hormone called luteinizing hormone (LH) that is produced by the pituitary gland. It stimulates the production of testosterone by the testicles. Agonists of the LH releasing hormone stop the production of luteinizing hormone by the pituitary gland. This lessens the production of testosterone in men. The cancer cells may then grow more slowly or stop growing altogether. Goserelin Acetate is a type of LHRH agonist. 

How to use Goserelin Acetate Implant?

Goserelin Acetate comes as an implant to be inserted with a syringe subcutaneously or under the skin. It is usually implanted in your stomach area given by a doctor or nurse in a medical office or clinic. An implant with 3.6 mg of this drug is usually inserted every 4 weeks. An implant with 10.8 mg is usually inserted every 12 weeks. The length of your treatment depends on the condition being treated and your response to the medication. Your doctor will determine how long you should use Goserelin Acetate Implant.

Goserelin Acetate may cause an increase in certain hormones in the first few weeks after insertion of the implant. Your doctor will monitor you carefully for any new or worsening symptoms during this time. 

What are the side effects of Goserelin Acetate Implant?

There are several things you can do to manage the side effects of this medication. Some of the side effects are:

  • Sweating
  • Hot flashes
  • Dizziness
  • Headache 
  • Vaginal dryness, itching, or discharge 
  • Mood changes 
  • Impotence
  • Increased or decreased interest in sex 
  • Breast swelling or tenderness
  • Fewer erections than normal
  • Nausea
  • Bone pain
  • Diarrhea
  • Vomiting
  • Loss of appetite
  • Constipation 
  • Sleep problems or insomnia
  • Mild skin rash or itching
  • Acne 

Call your doctor if you have these side effects:

  • Difficult or painful urination 
  • Bruising, pain, redness, swelling, bleeding or oozing where the implant was injected
  • Nerve problems 
  • High calcium levels
  • High blood sugar 
  • Signs of a stroke 

Things to tell your doctor before having this treatment:

  • Tell your doctor if you are allergic to this drug or if you have any allergies,
  • What prescriptions you are taking or any other medicines including vitamins or herbal supplements, 
  • If you have a history of drinking alcohol or using tobacco products for a long period,
  • If you have ever had diabetes, compressed spinal cord, urinary obstruction in men, or heart disease,
  • If you are pregnant or breastfeeding women. This should not be used in pregnant except for the treatment of advanced breast cancer.