Ethyol (Amifostine) for Injection

Amifostine General Information

Ethyol (Amifostine) is indicated to decrease the risk of kidney problems. It is caused by treatment with a certain anti-cancer drug called cisplatin. This may also be used to prevent a certain side effect. It may be caused by radiation treatment for head and neck cancer. 

How does Ethyol (Amifostine) for Injection work?

Ethyol (Amifostine) works by promoting the repair of damaged tissue. It also binds to harmful free radicals released by the cells. This drug is broken down by the body into other chemicals. It can deactivate harmful components of chemotherapy drugs.

Chemo-protective agents are medications used with certain types of chemotherapy. It is to protect the body from or minimize the side effects of the chemotherapy.  These medications do not eliminate side effects in general.  They keep the body from some of the possible serious side effects.  These also have side effects of their own so they are used only with specific types of chemotherapy. Those may also be used when the benefit clearly is greater than the risk. 

Why use Ethyol (Amifostine) for Injection?

Ethyol contains Amifostine as an active ingredient. It belongs to the class of medications known as cytoprotectants. It is a white crystalline powder which is freely soluble in water. Ethyol is the trihydrate form Amifostine. It is supplied as a sterile lyophilized powder requiring for intravenous infusion. Each single-use 10 mL vial has 500 mg of Amifostine. The Food and Drug Administration (FDA) approved this medication.

How to use Ethyol (Amifostine) for Injection?

The dosage will depend on your condition, age, and response.

This medication is given by injection into a vein by a doctor. It is usually given 15-30 minutes before cancer treatment.

To lessen the risk of certain side effects, your doctor may direct you to lie down while receiving this medication.

What are the side-effects of Ethyol (Amifostine) for Injection?

  • Nausea and vomiting
  • Drowsiness
  • Dizziness
  • ]chills
  • Unusual feelings of warmth or cold
  • Fever
  • Sneezing
  • General ill feeling
  • Hiccups

Warnings and Precautions

  • During pregnancy, this should only be used when needed. Discuss with your doctor the risks and benefits of this drug.
  • Do not use any machinery or do anything that needs your alertness. This medication may make you feel dizzy or drowsy.
  • Tell your doctor about the medical history you have and your current medications/treatments.
  • Tell also to your doctor if you are allergic to it or if you have any allergies. This may have an inactive ingredient that may cause an allergic reaction.