What condition does Eliglustat treat?

Eliglustat is used for the long-term treatment of Gaucher’s disease. It is a genetic disorder in which glucocerebroside accumulates in cells and certain organs. Glucocerebroside is a sphingolipid also known as glucosylceramide.

This medication can improve symptoms of Gaucher’s disease such as:

  • Tiredness
  • Bruising
  • Pain in the bones and joints
  • A swollen liver and spleen

Eliglustat is a small molecule inhibitor of glucosylceramide synthase. Glucosylceramide synthase is an enzyme that results in the reduced making of glucocerebroside. It is a fatty substance that unusually accumulates in the cells and tissues of those with Gaucher’s disease. The Food and Drug Administration (FDA) has already approved this medication.

How does Eliglustat work?

Eliglustat works by blocking the action of an enzyme involved in the production of glucosylceramide fat. It is because the build-up of this fat in organs like the liver, spleen, and bones is responsible for the symptoms of type-1 Gaucher’s disease. It reduces its production by helping it prevent its build-up. And thereby it helps the affected organs to function better.

What is the recommended dosage for Eliglustat?

Eliglustat is to be taken by mouth with a full glass of water. It is usually taken once or twice a day. You should not crush or chew the capsule swallow it as a whole. To help you remember, take it at the same time every day.

The dosage is based on your condition, response, and other medications you may be taking.

Avoid drinking grapefruit juice or eating grapefruit while using this medicine unless your doctor says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor for more details.

What are the side effects of Eliglustat?

  • Headache or migraine
  • Joint pain
  • Nausea
  • Gas
  • Fatigue
  • Mouth or throat pain
  • Diarrhea
  • Back pain
  • Abdominal pain
  • Pain in the extremities

What are the precautions in taking Eliglustat?

  • Before using this drug, discuss with your doctor the risks and benefits.
  • Tell your doctor if you have any medical history.
  • Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding while taking this medication.
  • Tell your doctor if you are allergic to it or if you have any allergies. This drug may contain an inactive ingredient that may cause an allergic reaction or other problems.
  • Limit alcoholic beverages while having this treatment.
  • Do not drive or do anything that requires your alertness. This medication may make you feel dizzy.
  • This medicine is not recommended for use in people with liver problems. This prescription may also not be recommended for people taking certain medicines that could interfere with the capability of the body to break down the medicine.
  • Inform your doctor if you have liver disease. Based on the results of your blood test to determine your genetic make-up, your doctor may tell you not to take this medicine. Certain people should not take the medication alone or along with other medications, especially if they have liver disease, or if they have a combination of certain medical conditions and medications.