Chloroquine

Chloroquine is in a class of drugs called antimalarials that is intended to prevent and treat malaria. This has become a front-line drug and the most prescribed medication worldwide. It is because this drug interferes with the growth of the parasite in the cells. For this reason Chloroquine has been deployed in the field by the experts to be used for the treatment of a pandemic disease known as COVID 19. When a protein spikes on its surface that binds to special receptors on the surface of human cells, SARS and COVID 19 infect humans. Against SARS, Chloroquine interferes with those receptors. By that, this drug decreases the ability of the virus to bind to cells. Researchers believed that Chloroquine can do the same against COVID 19.

COVID 19 is a new strain of coronavirus that is first identified in Wuhan, China. This virus is linked to the same family of viruses as a severe acute respiratory syndrome (SARS). COVID 19 is transmitted by direct contact with respiratory droplets of an infected person. The person may be generated through sneezing and coughing. The disease can also be transmitted by touching surfaces contaminated with the virus. COVID 19 may survive on surfaces for several hours but simple disinfectants can kill it. Symptoms can include cough, fever, or shortness of breath. In more severe cases, the infection can cause breathing difficulties. Here are some precautions that you can follow to avoid the infection:

⦁    Wah your hands often with soap and water or an alcohol-based hand rub

⦁    Cover mouth and nose with a tissue or flexed elbow when sneezing or coughing. Dispose of the used tissue right away.

⦁    Avoid close contact with anyone who has flu-like or cold symptoms

⦁    Seek medical care as soon as possible if you have a cough, fever, or difficulty breathing

How does Chloroquine work?

Chloroquine interferes with the ability of the virus to replicate in two ways:

(1) The drug comes in the compartments that are called endosomes within the cell membrane. The chemical structure of the drug boosts their pH and endosomes tend to be slightly acidic. It makes the compartments more basic. Many viruses acidify endosomes to breach the cell membrane. They release their genetic material and start to replicate. Chloroquine blocks this critical step.

(2) The drug prevents the virus from plugging into a receptor called angiotensin-converting enzyme-2 (ACE2) on primate cells. it sets off a chemical process alters the structure of the receptor when the virus inserts its spike protein into the ACE2 receptor. It also let the virus to infect. An adequate dose of Chloroquine appears to undermine this process. In turn, viral replication in general happens.

How to use Chloroquine?

Chloroquine comes as a tablet to be taken by mouth. Carefully follow the instructions given by your doctor. Ask your doctor to explain any part you don’t understand. The recommended dosage is based on your medical condition and response. The dosage in children is also based on weight. Do not take more or less or it or take it more often than the prescription. Take Chloroquine exactly as it is given by your doctor. You should not stop taking Chloroquine without your doctor’s consent. Skipping or changing your dose without the approval of your doctor may cause treatment to be ineffective.

Drink plenty of fluids while having this treatment. Take Chloroquine with food to prevent upset stomach. Swallow the tablet with a full glass of water. Do not chew or break it. If you forget a dose, take it as soon as you remember it. Nevertheless, skip the missed dose and continue your regular schedule of dose if it is almost time for your next dose. If your condition does not improve or gets worse, call your doctor at once. Click here to buy Chloroquine.

What are the possible side effects of the medicine Chloroquine?

Inform your doctor if you have side effects that won’t go away. It may include:

⦁    Stomach cramps

⦁    Mild headache

⦁    Nausea

⦁    Clumsiness

⦁    Dizziness

⦁    Mild diarrhea

⦁    Loss of appetite

Call your doctor right away if you have any of the following:

⦁    Severe diarrhea

⦁    Sensitivity to sunlight

⦁    Unusual behavior or mood changes

⦁    Ringing in the ears

⦁    Changes in skin color

⦁    Hearing loss

⦁    Hair and weight loss

⦁    Vomiting

⦁    Drowsiness

⦁    Loss of balance

⦁    Irregular heartbeats

If you have signs of an allergic reaction (hives, trouble breathing, or swelling of lips, face, or tongue), call for medical help right away.

Warnings and Precautions

⦁    Before taking Chloroquine, tell your doctor if you ever had hearing problems, liver disease, vision problems, psoriasis, seizures, kidney disease, or porphyria.

⦁    Let your doctor know if you drink a large amount of alcohol before starting this treatment.

⦁    Your doctor will probably want to order frequent tests to check the response of your body to Chloroquine.

⦁    Wear sunscreen and protective clothing when outdoors, avoid unnecessary sun exposure. Chloroquine may make your skin more sensitive to the sun.

⦁    Do not receive any vaccination while using this drug. Consult your doctor first.

⦁    Tell your doctor if you are pregnant or might become pregnant while taking Chloroquine. You will have to discuss the risks and benefits of using this medicine during pregnancy.

⦁    Don’t breastfeed while having this medication.

⦁    Your doctor may want to know if you ever had an allergic reaction to this drug or if you have any allergies – inform your doctor.

⦁    You should not share any of your medications with others even if they have the same symptoms as yours.

⦁    If you have any dietary instructions, follow it carefully. Continue your diet unless your doctor tells you otherwise.

⦁    Keep this drug on the container it came in, tightly closed, and far from the reach of children. Store Chloroquine at room temperature away from direct heat or moisture.

References:

the-scientist.com/news-opinion/is-hype-over-chloroquine-as-a-potential-covid-19-therapy-justified–67301/amp

medlineplus.gov.ph/druginfo/meds/a682318.html

google.com.ph/amp/s/qz.com/africa/1822701/coronavirus-trumpsays-malaria-drug-chloroquine-can-work/amp/