Avanafil is a prescription used for the treatment of erectile dysfunction (ED). ED is the inability to get and keep an erection firm enough for sex. Having erection trouble from time to time isn’t certainly a cause for concern. If ED is an ongoing issue, it can affect your self-confidence, cause stress, and contribute to relationship problems. Problems getting or keeping an erection can also be a sign of an underlying health condition that needs treatment and a risk factor for heart disease. Erectile dysfunction symptoms might include:

  • Trouble keeping an erection
  • Trouble getting an erection
  • Reduced sexual desire 

Male sexual arousal is a complex process that involves the brain, emotions, hormones, muscles, nerves, and blood vessels. ED can result from a problem with any of these. Also, stress and mental health concerns can cause or worsen ED. Sometimes a combination of physical and psychological issues causes erectile dysfunction. For instance, a minor physical condition that slows your sexual response might cause anxiety about maintaining an erection. The resulting anxiety can lead to or worsen erectile dysfunction. As you get older, erections might take longer to develop and might not be as firm. You might need a more direct touch to your penis to get and keep an erection. 

Avanafil is approved by the Food and Drug Administration (FDA). This medication is called a phosphodiesterase type-5 inhibitor. Avanafil prevents the action of a chemical in the body called phosphodiesterase type-5. This increases blood flow to the penis to help a man get and keep an erection. This prescription comes as a tablet for oral use with the dosage strengths of 50 mg, 100 mg, or 200 mg. 

How does Avanafil work?

An erection is made through a complex chain of events. Wherein, it involves signals from the nervous system and the release of chemical messengers within the tissues of the penis. One of these chemical messengers is called cyclic GMP. Cyclic GMP causes the blood vessels in the penis to widen. It is by relaxing a thin layer of muscle found in the blood vessel walls. This allows more blood to enter the penis. This ultimately results in the penis becoming rigid and erect. Cyclic GMP is usually broken down by another chemical in the body called phosphodiesterase type 5. 

Avanafil works by preventing the action of phosphodiesterase type 5. So, it stops the breakdown of cyclic GMP. This means that the blood vessels are kept dilated for longer, improving blood flow to the penis and maintaining an erection. As Avanafil enhances the actions of the chemical messengers responsible for producing an erection, it will only work once these messengers are present. This means that sexual stimulation is required for it to produce and maintain an erection. The dose should be taken approximately 30 minutes before you intend to have sex. 

How to use Avanafil?

Take this medication by mouth with or without food. This medication is taken usually as needed or as directed by your doctor. This medicine is available in different doses. Before the sexual activity, take Avanafil for about 15 minutes or 30 minutes depending on your dose. Follow your doctor’s instructions carefully on how many minutes before sexual activity you should take this medication. Do not take more than once daily. The tablet should be swallowed as a whole with a full glass of water. Do not chew, break, or crush it. Drink plenty of fluids while having this treatment. Doing so may lessen the risk of certain side effects. If you missed a dose, take it as soon as you remember it. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose to make up for the missed dose.

The dosage is based on your medical condition, response to the treatment, and other medications you are taking. Let your doctor know if your condition does not improve or if it gets worse. 

What are the side effects of Avanafil?

Common side effects:

  • Dizziness
  • Headache
  • Constipation
  • Diarrhea
  • Flushing (warmth or redness in your neck, face, or chest)
  • Cold symptoms (runny nose, stuffy nose, sinus pain, or sore throat)
  • Back pain
  • Stomach upset
  • Upper respiratory tract infection 
  • Bronchitis
  • Influenza
  • High blood pressure
  • Joint pain 

Stop using this medication and call your doctor if these side effects occur:

  • Sudden vision loss or vision changes
  • Ringing in your ears or sudden hearing loss
  • Shortness of breath
  • Swelling in your hands or feet
  • Swelling, pain, warmth, or redness in one or both legs
  • Penis erection that is painful or lasts 4 hours or longer

Get emergency medical help if you have signs of an allergic reaction such as: 

  • Hives
  • Difficulty breathing
  • Swelling of your throat, lips, face, tongue, or 

If other side effects occur, call your doctor right away. If there are any signs of an overdose, call for medical assistance as well. 

Warnings and Precautions

  • This drug may cause dizziness and visual disturbances. You should make sure you are aware of your reactions to this medicine before driving or operating machinery.
  • If you drink alcohol there is more chance of a drop in your blood pressure that might make you feel dizzy or faint. Also, alcohol can impair sexual performance.
  • If your erection lasts longer than four hours, consult a doctor right away. Treatment of this condition should not be delayed more than six hours. This can cause damage to the erectile tissue in the penis and irreversible erectile dysfunction.
  • After taking this medicine, if you do feel dizzy or lightheaded you should lie down until the symptoms pass.
  • If you experience a sudden loss of vision in one or both eyes you should stop taking this medicine and consult your doctor right away.
  • Avanafil should not be used in children under 18 years of age, men with severely decreased liver or kidney function, those with angina, and heart failure. 
  • Use this caution in men over 70 years old, men with an active peptic ulcer, and with disease involving the heart and blood vessels.