Anakinra

What condition does Anakinra treat?

Anakinra is an FDA-approved prescription used for the treatment of rheumatoid arthritis. This medicine helps to lessen joint pain and swelling caused by rheumatoid arthritis. It also slows joint damage to help you move better.

This prescription is also recommended for use for the treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID). This medication helps to improve symptoms of the disease such as:

  • Rash
  • Fever
  • Vomiting
  • Joint pain
  • Headache

Anakinra is a synthetic formula of a natural protein made by the body. This drug is an interleukin-1 (IL-1) receptor antagonist that helps block the effects of another protein which can cause joint swelling, pain, or stiffness.

How does Anakinra work?

Anakinra is a synthetic and injectable that blocks the effects of human interleukin-1 (IL-1). It is by competitively inhibiting IL-1 binding to the interleukin-1. In which it is expressed in a wide variety of tissues and organs.

Patients with rheumatoid arthritis have elevated levels of IL-1. In rheumatoid arthritis patients, the levels of the naturally occurring IL-1Ra are not enough to compete with the elevated amount of locally produced IL-1. Increasing the levels of IL-1Ra by synthetic means lessens the negative of IL-1. It is called cartilage degradation and bone resorption.

What is the recommended dosage for Anakinra?

  • The dosage is based on your medical condition and response to it.
  • This medication is injected under the skin usually once a day.
  • Let the medicine warm to room temperature for at least 30 minutes before injecting it.
  • Using rubbing alcohol, clean the injection site before injecting it.
  • Do not inject this medication in an area that is tender, bruised, red, hard, or which has scars or stretch marks.
  •  It is important to change the location of the injection site daily to avoid problem areas under the skin.
  • Do not inject this yourself. If you do not understand how to use the medicine properly, call your doctor.

What are the side effects of Anakinra?

  • Bruising
  • Redness
  • Pain at the injection site
  • Diarrhea
  • Nausea
  • Headache
  • Stomach pain
  • Cold symptoms such as sneezing, sore throat, or stuffy nose

What are the precautions in taking Anakinra?

  • Do not use the medication if it has changed color, looks cloudy, or has particles in it.
  • Tell your doctor if you ever had an allergic reaction to this medicine or if you ever had an allergic reaction.
  • Call your doctor right away if your condition does not improve or if they get worse while using this drug.
  • You should not reuse the syringe. Learn how to keep and discard needles safely.
  • While having this medication, do not have vaccinations or immunizations without the consent of your doctor.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are using this medication.
  • Inform your health care provider if you have or ever had asthma or kidney disease.
  • Older adults may be at greater risk for infections while using this drug.
  • Inform your doctor if you are using this medicine along with Abatacept, Etanercept, Adalimumab, and Certolizumab.