Amantadine Hydrochloride

Where is Amantadine Hydrochloride used?

Amantadine Hydrochloride is used for the treatment of;

  • Parkinson’s disease
  • Pain associated with shingles called herpes zoster

The Food and Drug Administration (FDA) has already approved this medication. This has pharmacological actions as both an anti-Parkinson’s and antiviral drug. Amantadine Hydrochloride restores the balance of certain natural substances in the brain. 

How does Amantadine Hydrochloride work?

Amantadine Hydrochloride works in different actions that allow it to control some of the symptoms of the disease.

  • It increases the activity of dopamine in the brain. Dopamine is known to be reduced or absent in the brains of people with Parkinson’s disease. By increasing the release of dopamine in the brain, Amantadine Hydrochloride replaces some of the lost dopamine. Therefore, it reduces some of the symptoms of the disease.
  • Amantadine Hydrochloride has a mild anticholinergic effect that prevents the activity of a neurotransmitter called acetylcholine. There is usually a balance between the activity of dopamine and the activity of acetylcholine in the brain. On the other hand, in Parkinson’s disease, the deficit of dopamine causes overactivity of acetylcholine. By decreasing the activity of acetylcholine, this medication helps restore the balance of acetylcholine and dopamine in the brain. This as well helps reduce some of the symptoms. 
  • This medication also affects a third neurotransmitter called glutamate. Overactivity of this neurotransmitter is also thought to play a role in causing the symptoms of Parkinson’s disease. Amantadine Hydrochloride blocks the receptors in the brain that glutamate usually acts on.
  • Amantadine Hydrochloride has a mild effect against some of the symptoms of Parkinson’s disease. But, after some time, several people find that the same dose becomes less effective and therefore its use may be limited. At times, the effectiveness can be restored if the medicine is stopped for a while and then restarted. You should tell your doctor if you notice this medication has become less effective. Amantadine Hydrochloride is usually used in combination with other medicines for the treatment of Parkinson’s disease.

How is Amantadine Hydrochloride taken?

Take this medication once a day, by mouth with or without food as directed by your doctor. The dosage is based on your medical condition and response to treatment. Take it at the same time each day to help you remember. Use this medication regularly to get the most benefit from it.

Do not stop taking this medication without consulting your doctor. If this drug is suddenly stopped or if your dose is quickly decreased your condition may get worse. Your doctor may gradually reduce your dose to lessen the chance of symptoms Tell your doctor right away if any new or worsening symptoms.

What are the precautions in taking Amantadine Hydrochloride?

  • Use Amantadine Hydrochloride with caution in elderly people and people with underlying psychiatric disorders. For people with kidney or liver disorders and with a history of disease involving the heart and blood vessels, this medication should be used with caution as well. 
  • Amantadine Hydrochloride may cause dizziness and blurred vision. It may affect your ability to perform hazardous activities safely. 
  • This drug should not be used in pregnant or breastfeeding women, with severe kidney disease, or those who suffer from fits. 
  • Let your doctor know if you have any other medications including herbal supplements or vitamins. 
  • While having this medication, limit alcoholic beverages.