Selegiline Hydrochloride

Selegiline Hydrochloride

SelegilineHydrochloride is a type of medicine called a selective monoamine-oxidase-Binhibitor. This is used for the treatment of Parkinson’s disease. Thisprescription has already approved by the Food and Drug Administration(FDA). 


Thisdisease affects movement and is a progressive nervous system disorder. Thesymptoms begin slowly and sometimes it starts with a barely noticeable tremorjust in one hand. Parkinson’s disease signs and symptoms can be different foreveryone. Early signs and symptoms can be mild and go unnoticed. Symptomsusually start on one side of your body and generally persist on that side evenafter symptoms begin to affect both sides. Some early symptoms may include:

  • Tremor especially in finger, hand, or foot
  • Cramped handwriting or writing changes
  • Limb stiffness or slow movement during sleep
  • Uncontrollable movements during sleep
  • Rigid facial expression or masking
  • Voice changes
  • Stooped posture

Parkinson’sdisease starts with the brain cells called neurons which control movement.Neurons create a substance called dopamine. The condition sets in when theneurons die and the levels of dopamine in the brain lessen. The lack ofdopamine is thought to result in the symptoms that affect the way youmove. 

Stages of Parkinson’sdisease

Stage 1: Thesymptoms are mild and only seen on one side of the body. There is usuallyminimal or no functional impairment. The symptoms may be so mild that doesn’tseek medical attention. Some symptoms may include: tremor, rigidity, one handor leg may feel clumsier, and one side of the face may be affected that itimpacts the expression. 

Stage 2: Thisis characterized by symptoms on both sides of the body or at the midlinewithout impairment to balance. At this stage, it may develop months or yearsafter stage 1. The symptoms may include decreased blinking, loss of facialexpression, soft voice, and speech abnormalities. However, at this stage, theperson with the disease is still able to do tasks of daily living. 

Stage 3: Thisstage is considerably a mild-stage. Stage 3 is characterized by slowness ofmovement and loss of balance. Balance is compromised by the inability to makethe rapid and automatic adjustments needed to prevent falling. Falls are commonat this stage. In this stage, the patient is still fully independent in theirdaily living activities like hygiene, dressing, and eating. 

Stage 4: Thepatient at this stage is unable to live an independent life. They already needassistance with some activities of daily living. 

Stage 5: This isthe most advanced and is characterized by an inability to rise from a chair orget out of the bed without help. They may tend to fall when standing orturning. They may freeze or stumble when walking. At this stage, assistance isneeded to lessen the risk of falling and help the patient with all dailyactivities. 

How doesSelegiline Hydrochloride work for Parkinson’s disease?

SelegilineHydrochloride increases the levels of a substance in the brain called dopamine.Dopamine is a substance known as a neurotransmitter. Neurotransmitters arepresent in the brain and nervous system. They are also involved in transmittingmessages between nerves. These messages allow the normal functioning of thebody. The neurotransmitter dopamine is known to lessen or absent in the brainsof people with Parkinson’s disease. It is also thought to be the cause ofdisease symptoms. The mainstay of treating the condition is to replace dopaminein the brain. 

Naturaldopamine released from nerve cells in the brain is normally broken down by anenzyme called monoamine-oxidase-B (MAO-B). Selegiline Hydrochloride works byblocking down this enzyme which prevents the MAO-B from breaking down thedopamine. This results in an increased amount of active dopamine in the brainand this decreases the symptoms of Parkinson’s disease. 

How touse Selegiline Hydrochloride?

SelegilineHydrochloride is taken by mouth usually twice a day with breakfast and lunch.Taking a dose of this drug late in the day may cause trouble sleeping. The dosagewill depend on your medical condition and response to the drug. Take thismedication as directed by your doctor for the best benefit. 

Thismedication is usually used in combination with a medicine called levodopa.Levodopa is converted into dopamine in the brain. It works by directlyreplacing the lost dopamine. Unfortunately, levodopa treatment tends to becomeless effective over time. It is where the effect of each dose of levodopabecomes progressively shorter. Selegiline Hydrochloride can be used to prolongthe effect of levodopa. It stops the dopamine that is formed from the levodopafrom being broken down in the brain. This extends the action of levodopathereby reducing certain side effects.

After youhave been taking Selegiline Hydrochloride for 2-3 days, your doctor may directyou to lower your levodopa dose. Follow your doctor’s instructions carefully.Do not stop or change the dose of any of your medications without the consentof your doctor. It may take a few weeks for the full benefits of the drug to benoticed. 

What arethe side effects of Selegiline Hydrochloride?

  • Abdominal pain
  • Dizziness
  • Nausea
  • Dry mouth
  • Trouble sleeping
  • Stomach upset
  • Weakness
  • Headache
  • Back pain
  • Runny or stuffy nose 
  • Constipation
  • Pain with swallowing
  • Mouth sores or ulcers
  • Pain, redness, or swelling of the mouth and throat 

Informyour doctor at once if you experience:

  • Loss of balance
  • Fainting 
  • Worsening muscle stiffness or twitching
  • Unusual strong urges 
  • Increased shaking 
  • Unusual weight gain
  • Easy bruising or bleeding
  • Difficulty urinating
  • Vomit that looks like coffee grounds 


  • Do not drink alcoholic beverages while taking this drug. 
  • This drug may affect your ability to perform some activities especially when driving or operating machinery. 
  • People with decreased liver function, history of peptic ulcers, severe angina, or unstable high blood pressure, Selegiline Hydrochloride should be used with caution. 
  • Selegiline Hydrochloride is not recommended for use in people with active peptic ulcer or hereditary blood disorders called acute porphyrias. 
  • Consult your doctor first if you are pregnant or breastfeeding women before taking Selegiline Hydrochloride. 
  • Let your doctor if you have any allergies or if you are allergic to this drug.