Ruxolitinib Tablet

Ruxolitinib Tablet


Ruxolitinib Tablet is indicated touse on a certain bone marrow disorders such as:

  • Polycythemia Vera

This is a slow-growing bloodcancer in which your bone marrow creates a lot of red blood cells. These cellsthicken your blood and slowing its flow. They may also cause complications likeblood clots. That it leads to a heart attack or stroke.

  • Myelofibrosis

This is an unusual type of bonemarrow cancer that interrupts your body’s normal making of blood cells. Itcauses extensive scarring in your bone marrow leading to severe anemia that cancause weakness.

This medication is not a cure forthese disorders, but it may help with some of the symptoms such as:

  • Night sweats
  • Bone or muscle pain
  • Itching
  • Pain under left ribs
  • Abdominal discomforts
  • Early feelings of fullness from meals

Howdoes Ruxolitinib Tablet work?

Ruxolitinib is a kinase inhibitorthat is selective for the Janus Associated Kinases (JAK) 1 and 2. These areresponsible for the mediation of cytokine and growth factor signalling. Whichin turn it affects immune function and hematopoiesis. The signalling processinvolves signal transducers and transcriptions activators (STAT). In which itis the one that modulates the gene expression. People with Myelofibrosis haveabnormal JAK1 and JAK2. Thus, this medication works to regulate this condition.

Whyuse Ruxolitinib Tablet?

Ruxolitinib Tablet belongs to theclass of medications called JAK inhibitors. This has the brand name of Jakafi.Ruxolitinib is the active ingredient of this product. This comes as a tabletfor oral use. Each tablet has the strengths of 5 mg, 10 mg, 15 mg, 20 mg, and25 mg. The U.S. Food and Drug Administration (FDA) has already approved thisprescription.  

Howto use Ruxolitinib Tablet?

Ruxolitinib Tablet is to be takenby mouth with or without a meal. Each dose is usually taken twice a day. If youhave the difficulty to swallow the tablet as a whole, call your doctor foranother way to take it. Remember to take each tablet at the same time everyday.

The dosage is based on yourmedical condition and response to it. Take it exactly as it is prescribed. Donot take more than or more often than it is directed by your doctor.

Whatare the side-effects of Ruxolitinib Tablet?

  • Dizziness
  • Bruising
  • Weight gain
  • Headache
  • Gas
  • Bloating
  • Fatigue
  • Anemia
  • Diarrhea
  • Nausea
  • Shortness of breath
  • Body aches
  • Sores in your mouth or throat
  • Pale skin
  • Flu symptoms

Warningsand Precautions

  • Before using this medication, tell your doctor ifyou have a medical history of kidney or liver disease.
  • Do not drive or perform any activity that requiresalertness. This medicine may make you dizzy.
  • Limit alcoholic beverages while using thisprescription.
  • If you are pregnant or breastfeeding women,consult your doctor first before using.
  • Avoid eating grapefruit or drinking grapefruitjuice.
  • Keep this at room temperature away from heat andmoisture.