Pramipexole Dihydrochloride

Pramipexole Dihydrochloride

Pramipexole Dihydrochloride is a prescription used for the treatment of Parkinson’s disease. It is a progressive neurological disorder and has the first sign of problems with movements. In Parkinson’s disease, the cells of substantia nigra start to die. Smooth and coordinated muscle movements of the body are made possible by a substance in the brain called dopamine. Dopamine is produced in a part of the brain called the ‘substantia nigra’. Parkinson’s is a type of disease that is chronic and worsens over time. Symptoms begin gradually, often on one side of the body and later they will affect both sides. They include:

  • Stiffness of the arms, trunk, and legs
  • Trembling of hands, legs, arms, jaw, and face
  • Poor balance and coordination
  • Slowness of movement

As symptoms worsen, people with this type of disease may have trouble walking, talking, or do simple tasks. They may also have problems such as trouble chewing, depression, sleep problems, or trouble speaking. Parkinson’s disease usually begins around the age of 60 but it can start earlier. It is more common in men than in women.

This medication may also be usedfor the treatment of restless legs syndrome (RLS). RLS causes an uncontrollableurge to move your legs. Usually, it is because of an uncomfortable sensation. Ittypically occurs in the evening or nighttime hours when you are sitting orlying down. Moving eases the unpleasant feeling temporarily. The chief symptomis an urge to move the legs.

Pramipexole Dihydrochloride helpsimprove your ability to move and lessen shakiness or tremors in Parkinson’sdisease. It also improves slowed movement and unsteadiness. In RLS, thismedication can decrease the symptoms and thereby improve sleep. PramipexoleDihydrochloride is a dopamine agonist that helps restore the balance of acertain natural substance in the brain. The Food and Drug Administration (FDA)has already approved this prescription. This is supplied as tablets for oraluse. Each tablet is available in the dosage forms of 0.125 mg, 0.25 mg, 0.5 mg,0.75 mg, 1 mg, and 1.5 mg.

Howdoes Pramipexole Dihydrochloride work?

PramipexoleDihydrochloride works by imitating the activity of a substance in the braincalled dopamine. Dopamine is a substanceknown as a neurotransmitter. Neurotransmitters are present in the nervoussystem and in the brain. These are also involved in transmitting messagesbetween nerves. These messages allow the normal functioning of the body. Theneurotransmitter dopamine is known to be reduced in the brains of people withParkinson’s disease. This is thought to be the cause of disease symptoms. Dopamineusually transmits messages by stimulating specific receptor sites in the brain.This medication stimulates these same receptor sites. This creates the sameeffects as dopamine and acts as a dopamine substitute. In this way, Pramipexolehelps to restore the dopamine activity in the brain which helps lessen thesymptoms of Parkinson’s disease.

Howto use Pramipexole Dihydrochloride?

Pramipexole Dihydrochloride is tobe taken by mouth as directed by your doctor. You may take each tablet with orwithout a meal. The prescribed dosage is based on your medical condition andresponse to the treatment. Your doctor may direct you to start at a lower doseand eventually increase it. Do not suddenly stop taking PramipexoleDihydrochloride without the consent of your doctor. It is important to continuetaking this even if you feel well. It is important that you take thismedication exactly as it is given by your doctor. You should not take less ormore often than the prescription.

To help you remember, take it atthe same time and in the same way each day. Swallow the tablet as a whole witha full glass of water. Do not break, chew, or crush it. Drink plenty of fluidswhile having this treatment. Doing so may lessen the risk of certain sideeffects. If you missed a dose, take it as soon as you remember it. If it isalmost time for your next dose, skip the missed dose and continue your regulardosing schedule. Do not double the dose to make up for the missed dose. Letyour doctor know if your condition worsens or does not improve.


Whatare the side effects of Pramipexole Dihydrochloride?

Common side effects:

  • Nausea
  • Dizziness when standing
  • Stomach pain
  • Dry mouth
  • Constipation
  • Vomiting
  • Spinning sensation
  • Headache
  • Swelling in your hands and feet
  • Drowsiness
  • Blurred vision
  • Appetite or weight changes
  • Memory problems
  • Sleep problems (unusual dreams or insomnia)
  • Confusion or thinking problems
  •  Forgetfulness
  • Impotence or trouble having an orgasm

Call your doctor right away ifthese occur:

  • Hallucinations
  • A light-headed feeling like you might pass out
  • Falling asleep suddenly
  • Extreme drowsiness
  • Vision problems
  • Unexplained muscle pain, weakness, or tenderness
  • Posture changes you cannot control

Warningsand Precautions

  • Before using Pramipexole Dihydrochloride, let your doctor know if you had any medical history especially of heart problems, low blood pressure, and kidney problems.
  • It is recommended that people with heart disease should have their blood pressure monitored during treatment with this medicine. Particularly, it is at the start due to the risk of drops in blood pressure.
  • You should exercise caution when driving or performing any activities. This drug may cause dizziness or sleepiness.
  • Caution should also be observed when drinking alcohol or taking other medicines that cause drowsiness, as this may increase the risk of drowsiness.
  • Consult your doctor if you have any disturbances in your vision while taking Pramipexole Dihydrochloride.
  • Use this medication with caution in people with decreased kidney function, psychotic illness, and severe disease involving the heart and blood vessels.
  • This should not be used in pregnant or breastfeeding women.
  • The safety and efficacy of this drug have not been established in children and adolescents less than 18 years of age.
  • If you have an allergic reaction to this drug before, do not use it anymore and inform your doctor. This may contain an inactive ingredient that causes an allergic reaction.
  • Do not share this or any of your medications with others even if they have the same symptoms as yours.