Pertuzumab is an anti-cancer or cytotoxic chemotherapy drug used for the treatment of HER2-positive breast cancer. This is a type of cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2). In which it promotes the growth of cancer cells. Breast cancer symptoms vary widely; from lumps to swelling to skin changes and many breast cancers have no obvious symptoms at all. Some signs and symptoms may include:

  • Skin irritation or dimpling
  • Swelling of all or part of the breast
  • Nipple pain or the nipple turning inward
  • Breast pain
  • A nipple discharge other than breast milk
  • Scaliness, redness, or thickening of the nipple orbreast skin
  • A lump in the underarm area

These changes can also be signsof less serious conditions that are not cancerous. It’s important to get anybreast changes checked out promptly by a doctor. HER2 is present in excessiveamounts on the surface of some cancer cells. Its presence stimulates the growthof these cancer cells.

This medication is in the classof medications called monoclonal antibodies. This blocks the growth and spreadof cancer. They target and interfere with processes in the cells that causecancer to grow. This binds to a different area of the HER2 protein. Pertuzumab injectionis a sterile, clear to slightly opalescent, and colorless to pale brown liquidfor intravenous use. Each single-use vial contains 420 mg of Pertuzumab at aconcentration of 30mg/mL.

Howdoes Pertuzumab work?

Pertuzumab works in a similar wayto the natural antibodies produced by our immune system. Our natural antibodiesrecognize foreign invaders and bind to them. This helps our immune systems toattack them and protect us from infections. Monoclonal antibodies like thisdrug are effective in attacking cancer cells.

This drug specifically recognizesand binds to the HER2 protein on breast cancer cells. This stops the cancercells from growing and multiplying. Pertuzumab also triggers the immune systemto attack and kill the cancerous cells. This prescription only works in peoplewho have high levels of the HER2 protein. There may be various tests to measurethe levels of HER2.

Howto use Pertuzumab?

This medication is to be injectedslowly into a vein as directed by your doctor. This is usually given once every3 weeks. Your first infusion will be given over 60 minutes. The dosage, thespeed of your injection, and the length of time you receive this drug is basedon your condition and response to the treatment. It may as well depend on othertreatment that you are taking. Your doctor may direct you to start at a lowdose and gradually increase it. You must take each dose exactly as it isprescribed. Do not take more or less than it is given by your doctor. Yourdoctor should watch you for at least 60 minutes after your first infusion isfinished. To make sure you do not have an infusion reaction, your doctor willcheck also for at least 30 minutes after the following infusions.

Before using this product, checkit visually for discoloration or particles. Do not use the liquid if either ispresent. Clean the injection with rubbing alcohol before injecting each dose.Learn how to store and discard medical supplies safely. To get the most benefitfrom it, use the medication regularly. Remember to use the prescription at thesame time each day. If you missed a dose, take it as soon as you remember it.If it is almost time for your next dose, skip the missed dose and follow yourregular schedule. Inform your doctor if your condition gets worse or does notimprove.

Whatare the side effects of Pertuzumab?

Common side effects:

  • Diarrhea
  • Vomiting
  • Nausea
  • Heart problems
  • Loss of appetite
  • Tiredness
  • Dry skin
  • Itching or rash
  • Numbness or tingling in your hands
  • Cold symptoms such as sneezing, stuffy nose, orsore throat
  • Temporary hair loss

Call your doctor right away ifyou these unlikely but serious side effects:

  • New or worsening cough or shortness of breath
  • Dizziness, pounding heartbeats or fluttering inyour chest
  • Swelling in your lower legs
  • Low blood cell counts (mouth sores, chills, skinsores, unusual bleeding, or pale skin)
  • Signs of tumor cell breakdown (weakness, confusion,nausea, muscle cramps, vomiting, or tingling in your hands/feet/around yourmouth)

Get emergency medical help if youhave any signs of an allergic reaction:

  • Difficulty breathing
  • Hives or itching
  • Swelling of your lips, face, tongue, or throat

Warningsand Precautions

  • Before taking Pertuzumab, tell your doctor if youare allergic to it. This may not be recommended for use if you have a historyof an allergic reaction. Tell as well if you have any allergies. This drug maycontain an inactive ingredient that causes an allergic reaction.
  • You may experience infusion-related reactionswhile having this treatment. These are usually mild to moderate but can be moresevere.
  • This drug has been associated with causing heartfailure. For this reason, your heart function will be checked before treatmentis started and regularly throughout your treatment.
  • Pertuzumab may lower the number of healthy whiteblood cells in your blood. It may increase your risk of getting infections.
  • As medicine may be harmful to an unborn baby,women who could get pregnant should use effective contraception. It is toprevent pregnancy both during treatment and for at least 6 months aftertreatment is finished.
  • Before starting this treatment, discuss with yourdoctor about fertility. Your ability to become pregnant or father a child maybe affected.
  • Consult your doctor first if you are breastfeedingwomen.
  • This prescription should be used with caution in elderlypeople over 65 years old, those who have a history of heart failure, and otherheart diseases such as an irregular heartbeat.
  • You should also use this with caution in peoplewith decreased liver function or severely decreased kidney function.
  • Do not have any immunizations or vaccinationswithout the consent of your doctor.
  • Keep this far from heat, moisture, and reach ofchildren/pets.