Natalizumab

Natalizumab

GeneralInformation

Natalizumab is indicated for thetreatment of relapsing multiple sclerosis (MS). In MS the central nervous system whichincludes the brain and spinal cord become damaged. MS causes the immune systemto attack the myelin which is the insulation protecting the nerves. Thismedication helps to prevent your immune system from attacking the nerves inyour brain and spinal cord.

Natalizumab may also be used totreat bowel condition called Crohn’s disease (CD). This is used when it ismoderate to severe and keeps coming back. This helps prevent the immune systemfrom causing inflammation or swelling within your bowels.

Howdoes Natalizumab work?

Natalizumab binds to a specific receptor knownas an integrin. It is found on the surface of white blood cells calledleucocytes. The leucocytes are involved in producing inflammation. It isbelieved that brain lesions in multiple sclerosis occur when certain leucocytesmove out of the blood and into the brain. Blocking the integrin receptors onthe leucocytes stops them from moving from the blood into the brain. This lessensinflammation in the brain and decreases the enlargement of brain lesions. Thatit may result in the nerve damage caused by multiple sclerosis.

Whyuse Natalizumab?

Natalizumab is a type of medicinecalled human monoclonal antibody. This helps decrease the number of episodes ofworsening and may prevent or delay disability. This medication is supplied as asterile, colorless, and clear to slightly opalescent concentrate forintravenous infusion. Each 15 ml dose contains 300 mg of Natalizumab. The Foodand Drug Administration (FDA) has already approved this prescription.

Howto use Natalizumab?

The recommended dosage is basedon your medical condition and response. To lessen your risk of side effects,your doctor may start you at a low dose and slowly increase your dose. Do nottake more or less of this medication.

Natalizumab is given by a healthcareprofessional. This is usually given every 4 weeks or as directed by yourdoctor. This medication is mixed in a solution and injected slowly into a veinusually over an hour. Do not miss any doses without your doctor’s consent.

Whatare the side effects of Natalizumab?

  • Tired feeling
  • Headache
  • Muscle or joint pain
  • Redness or irritation at the injection site’
  • Diarrhea
  • Stomach pain
  • Skin rash
  • Painful menstrual cramps
  • Swelling of the hands, feet, or ankles
  • Nausea
  • Dizziness
  • Fever
  • Chest pain
  • Flushing

Warningsand Precautions

  • Before using this medication, tell your doctor ifyou are allergic to it. Tell as well if you have any medical history especiallyof depression or organ transplant.
  • If you are pregnant or planning to become pregnant,consult your doctor first before using this.
  • This may not be recommended for use bybreastfeeding women.
  • Do not share this with others even if they havethe same symptoms as yours.