Goserelin Acetate Implant

Goserelin Acetate Implant

What isGoserelin Acetate Implant and how does it work?

GoserelinAcetate is in the class of medication called gonadotropin-releasing hormone(GnRH) agonists. This is used;

  • In combination with radiation therapy and other medications to treat localized prostate cancer 
  • Alone to treat symptoms associated with advanced prostate cancer
  • To treat advanced breast cancer in certain women 
  • To manage endometriosis
  • To help with the treatment of abnormal bleeding of the uterus 

Mostprostate cancers need supplies of the male hormone testosterone to grow.Testosterone is an androgen produced by the testes and adrenal glands. Theproduction of testosterone can be stopped by surgically removing the testiclesor through medication therapy. A hormone called luteinizing hormone (LH) thatis produced by the pituitary gland. It stimulates the production oftestosterone by the testicles. Agonists of the LH releasing hormone stop theproduction of luteinizing hormone by the pituitary gland. This lessens theproduction of testosterone in men. The cancer cells may then grow more slowlyor stop growing altogether. Goserelin Acetate is a type of LHRH agonist. 

How touse Goserelin Acetate Implant?

GoserelinAcetate comes as an implant to be inserted with a syringe subcutaneously orunder the skin. It is usually implanted in your stomach area given by a doctoror nurse in a medical office or clinic. An implant with 3.6 mg of this drug isusually inserted every 4 weeks. An implant with 10.8 mg is usually insertedevery 12 weeks. The length of your treatment depends on the condition beingtreated and your response to the medication. Your doctor will determine howlong you should use Goserelin Acetate Implant.

GoserelinAcetate may cause an increase in certain hormones in the first few weeks afterinsertion of the implant. Your doctor will monitor you carefully for any new orworsening symptoms during this time. 

What arethe side effects of Goserelin Acetate Implant?

There areseveral things you can do to manage the side effects of this medication. Someof the side effects are:

  • Sweating
  • Hot flashes
  • Dizziness
  • Headache 
  • Vaginal dryness, itching, or discharge 
  • Mood changes 
  • Impotence
  • Increased or decreased interest in sex 
  • Breast swelling or tenderness
  • Fewer erections than normal
  • Nausea
  • Bone pain
  • Diarrhea
  • Vomiting
  • Loss of appetite
  • Constipation 
  • Sleep problems or insomnia
  • Mild skin rash or itching
  • Acne 

Call yourdoctor if you have these side effects:

  • Difficult or painful urination 
  • Bruising, pain, redness, swelling, bleeding or oozing where the implant was injected
  • Nerve problems 
  • High calcium levels
  • High blood sugar 
  • Signs of a stroke 

Things totell your doctor before having this treatment:

  • Tell your doctor if you are allergic to this drug or if you have any allergies,
  • What prescriptions you are taking or any other medicines including vitamins or herbal supplements, 
  • If you have a history of drinking alcohol or using tobacco products for a long period,
  • If you have ever had diabetes, compressed spinal cord, urinary obstruction in men, or heart disease,
  • If you are pregnant or breastfeeding women. This should not be used in pregnant except for the treatment of advanced breast cancer.