Chloroquine

Chloroquine

Chloroquine is in aclass of drugs called antimalarials that is intended to prevent and treatmalaria. This has become a front-line drug and the most prescribed medicationworldwide. It is because this drug interferes with the growth of the parasitein the cells. For this reason Chloroquine has been deployed in the field by theexperts to be used for the treatment of a pandemic disease known as COVID 19.When a protein spikes on its surface that binds to special receptors on thesurface of human cells, SARS and COVID 19 infect humans. Against SARS,Chloroquine interferes with those receptors. By that, this drug decreases theability of the virus to bind to cells. Researchers believed that Chloroquinecan do the same against COVID 19.

COVID 19 is a newstrain of coronavirus that is first identified in Wuhan, China. This virus islinked to the same family of viruses as a severe acute respiratory syndrome(SARS). COVID 19 is transmitted by direct contact with respiratory droplets ofan infected person. The person may be generated through sneezing and coughing.The disease can also be transmitted by touching surfaces contaminated with thevirus. COVID 19 may survive on surfaces for several hours but simpledisinfectants can kill it. Symptoms can include cough, fever, or shortness ofbreath. In more severe cases, the infection can cause breathing difficulties.Here are some precautions that you can follow to avoid the infection:

⦁    Wah your hands often with soap and water oran alcohol-based hand rub

⦁    Cover mouth and nose with a tissue orflexed elbow when sneezing or coughing. Dispose of the used tissue right away.

⦁    Avoid close contact with anyone who hasflu-like or cold symptoms

⦁    Seek medical care as soon as possible ifyou have a cough, fever, or difficulty breathing

How doesChloroquine work?

Chloroquineinterferes with the ability of the virus to replicate in two ways:

(1) The drug comesin the compartments that are called endosomes within the cell membrane. Thechemical structure of the drug boosts their pH and endosomes tend to beslightly acidic. It makes the compartments more basic. Many viruses acidifyendosomes to breach the cell membrane. They release their genetic material andstart to replicate. Chloroquine blocks this critical step.

(2) The drugprevents the virus from plugging into a receptor called angiotensin-convertingenzyme-2 (ACE2) on primate cells. it sets off a chemical process alters thestructure of the receptor when the virus inserts its spike protein into theACE2 receptor. It also let the virus to infect. An adequate dose of Chloroquineappears to undermine this process. In turn, viral replication in generalhappens.

How to useChloroquine?

Chloroquine comesas a tablet to be taken by mouth. Carefully follow the instructions given byyour doctor. Ask your doctor to explain any part you don’t understand. Therecommended dosage is based on your medical condition and response. The dosagein children is also based on weight. Do not take more or less or it or take itmore often than the prescription. Take Chloroquine exactly as it is given byyour doctor. You should not stop taking Chloroquine without your doctor’sconsent. Skipping or changing your dose without the approval of your doctor maycause treatment to be ineffective.

Drink plenty of fluids while having this treatment. Take Chloroquine with food to prevent upset stomach. Swallow the tablet with a full glass of water. Do not chew or break it. If you forget a dose, take it as soon as you remember it. Nevertheless, skip the missed dose and continue your regular schedule of dose if it is almost time for your next dose. If your condition does not improve or gets worse, call your doctor at once. Click here to buy Chloroquine.

What are thepossible side effects of the medicine Chloroquine?

Inform your doctorif you have side effects that won’t go away. It may include:

⦁    Stomach cramps

⦁    Mild headache

⦁    Nausea

⦁    Clumsiness

⦁    Dizziness

⦁    Mild diarrhea

⦁    Loss of appetite

Call your doctorright away if you have any of the following:

⦁    Severe diarrhea

⦁    Sensitivity to sunlight

⦁    Unusual behavior or mood changes

⦁    Ringing in the ears

⦁    Changes in skin color

⦁    Hearing loss

⦁    Hair and weight loss

⦁    Vomiting

⦁    Drowsiness

⦁    Loss of balance

⦁    Irregular heartbeats

If you have signsof an allergic reaction (hives, trouble breathing, or swelling of lips, face,or tongue), call for medical help right away.

Warnings andPrecautions

⦁    Before taking Chloroquine, tell your doctorif you ever had hearing problems, liver disease, vision problems, psoriasis,seizures, kidney disease, or porphyria.

⦁    Let your doctor know if you drink a largeamount of alcohol before starting this treatment.

⦁    Your doctor will probably want to orderfrequent tests to check the response of your body to Chloroquine.

⦁    Wear sunscreen and protective clothing whenoutdoors, avoid unnecessary sun exposure. Chloroquine may make your skin moresensitive to the sun.

⦁    Do not receive any vaccination while usingthis drug. Consult your doctor first.

⦁    Tell your doctor if you are pregnant ormight become pregnant while taking Chloroquine. You will have to discuss therisks and benefits of using this medicine during pregnancy.

⦁    Don’t breastfeed while having thismedication.

⦁    Your doctor may want to know if you everhad an allergic reaction to this drug or if you have any allergies – informyour doctor.

⦁    You should not share any of yourmedications with others even if they have the same symptoms as yours.

⦁    If you have any dietary instructions,follow it carefully. Continue your diet unless your doctor tells you otherwise.

⦁    Keep this drug on the container it came in,tightly closed, and far from the reach of children. Store Chloroquine at roomtemperature away from direct heat or moisture.

References:

the-scientist.com/news-opinion/is-hype-over-chloroquine-as-a-potential-covid-19-therapy-justified–67301/amp

medlineplus.gov.ph/druginfo/meds/a682318.html

google.com.ph/amp/s/qz.com/africa/1822701/coronavirus-trumpsays-malaria-drug-chloroquine-can-work/amp/