Abiraterone Acetate

Abiraterone Acetate

AbirateroneAcetate is a type of medicine known as an androgen biosynthesis inhibitor or anandrogen. This is used for prostate cancer that has spread to other parts ofthe body. Abiraterone Acetate has a dosage strength of 125 mg. The Food andDrug Administration (FDA) has already approved this prescription. 

Theprostate is a small walnut-shaped gland in men that creates the seminal fluid.Prostate cancer is one of the most common types of cancer in men. Usually,cancer grows slowly and is initially confined to the prostate gland, where itmay not cause serious harm. However, while some types of prostate cancer growslowly and may need minimal or even no treatment, other types are aggressiveand can spread quickly. More advanced prostate cancer may cause signs andsymptoms such as:

  • Trouble urinating
  • Blood in semen
  • Decreased force in the stream of urine
  • Discomfort in the pelvic area
  • Erectile dysfunction
  • Bone pain

You canreduce your risk of prostate cancer if you:

1. Choose a healthy diet full of fruits and vegetables

Avoidhigh-fat foods and instead focus on choosing a variety of fruits, vegetables,and whole grains. Fruits and vegetables contain many vitamins and nutrientsthat can contribute to your health. Whether you can prevent prostate cancerthrough diet has yet to be conclusively proved. But eating a healthy diet witha variety of fruits and vegetables can improve your overall health.

2. Choose healthy foods over supplements

Nostudies have shown that supplements play a role in reducing your risk ofprostate cancer. Instead, choose foods that are rich in vitamins and mineralsso that you can maintain healthy levels of vitamins in your body.

3. Exercise most days of the week

Exerciseimproves your overall health. It helps you maintain your weight and improvesyour mood. Try to exercise most days of the week. If you’re new to exercise,start slow, and work your way up to more exercise time each day.

4. Maintain a healthy weight

Work tomaintain your healthy weight by exercising most days of the week. If you needto lose weight, add more exercise, and reduce the number of calories you eateach day. 

5. Talk to your doctor about the increased risk of prostate cancer

Men witha high risk of prostate cancer may consider medications or other treatments toreduce their risk.

Doctorsknow that prostate cancer begins when some cells in your prostate becomeabnormal. Mutations in the abnormal cells’ DNA cause the cells to grow morerapidly than normal cells do. The abnormal cells continue living when othercells would die. The accumulating abnormal cells form a tumor that can grow toinvade nearby tissue. Some abnormal cells can also break off and spread toother parts of the body.

How doesAbiraterone Acetate work?

Prostatecancers are sensitive to testosterone and their growth is increased in thepresence of this hormone. Testosterone is produced by the testicles, theadrenal glands, and by cells in the prostate tumor itself. 

AbirateroneAcetate works by preventing the action of an enzyme called cytochrome P17. Theenzyme is also involved in the production of testosterone. This enzyme is foundin the testicles, the adrenal glands, and the tissues of the prostate tumor. Byinhibiting the activity of this enzyme in all these places, the amount oftestosterone in the body is reduced more than by medical castration. This helpsdecrease the growth of prostate cancer cells. 

Standardtreatment for prostate cancer that has spread beyond the prostate glandinvolves stopping the production of testosterone by the testicles. It is toslow the growth of the cancer cells. This is usually achieved with medicinescalled LHRH or gonadorelin analogs or with surgery to the testicles. 

How touse Abiraterone Acetate?

AbirateroneAcetate is to be taken by mouth on an empty stomach at least 1 hour before or 2hours after food. This is usually taken once a day or as directed by yourdoctor. The dosage is based on your mei9dcal condition and response to thetreatment. Taking this medicine with food greatly increases the amount of thedrug in your body and increases the risk of side effects as well. 

You needto swallow the whole medicine and don’t chew or break it. Use this medicationregularly to get the most benefit from it. To help you remember, take it at thesame time each day. Do not stop any prescription that has given for thetreatment of prostate cancer unless your doctor tells you to do so. Stoppingthe medications will allow cancer to spread more quickly. 

What arethe side effects of Abiraterone Acetate?

  • Joint swelling or discomfort
  • Diarrhea
  • Fatigue
  • Vomiting
  • Shortness of breath
  • Cough
  • Edema
  • Bruising
  • High blood pressure
  • Urinary tract infection 

If theseside effects persist or get worse, call your doctor right away. 

Warnings 

  • This drug may cause liver problems. For this reason, your doctor will want you to have blood tests to monitor your liver function. 
  • Your blood pressure and the level of potassium in your blood should also be checked every month. You should tell your doctor if you have any signs of fluid retention. 
  • Women who are or could be pregnant should wear gloves if they need to touch or handle Abiraterone Acetate. 
  • Use this with caution in people with decreased liver function, severely decreased kidney function or high blood pressure. People with a history of heart disease, with a low level of potassium in their blood, and on a low sodium diet, this medication should also be used with caution. 
  • This is not for use in women and men with severely decreased liver function. 
  • Abiraterone Acetate should not be taken by people with rare hereditary problems of galactose intolerance or glucose-galactose malabsorption. 
  • This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor right away.